Attitudes to E-Cigarettes and Cessation Support for Pregnant Women from English Stop Smoking Services: A Mixed Methods Study

Smoking in pregnancy remains a public health problem. In the UK e-cigarettes are the most popular aid to quitting smoking outside of pregnancy, but we don’t know the extent of e-cigarette use in pregnancy or how English Stop Smoking Services (SSS) respond to pregnant women who vape. In 2015 we surveyed SSS managers about cessation support for pregnant women and responses to clients who vaped. Subsequently we interviewed a sub-sample of managers to seek explanations for the SSS’ position on e-cigarettes; interviews were thematically analysed. Survey response rate was 67.8% (72/106); overall managers reported 2.2% (range 1.4–4.3%) of pregnant clients were using e-cigarettes. Most SSS reported supporting pregnant women who already vaped, but would not recommend e-cigarette use; for women that were still smoking and not using e-cigarettes, 8.3% of SSS were likely/very likely to advise using e-cigarettes, with 56.9% of SSS unlikely/very unlikely to advise using them. Fifteen respondents were interviewed; interviewees were generally positive about the potential of e-cigarettes for cessation in pregnancy although concerns about perceived lack of evidence for safety were expressed and most wanted research on this. Clear guidance on e-cigarette use informed by pregnancy specific research will assist SSS to provide consistent evidence-based support

Effect of offering different levels of support and free nicotine replacement therapy via an English national telephone quitline: randomised controlled trial

Objective To compare the effects of free nicotine replacement therapy or proactive telephone counselling in addition to standard smoking cessation support offered through a telephone quitline

CONDOR: a database resource of developmentally associated conserved non-coding elements

<p>Abstract</p> <p>Background</p> <p>Comparative genomics is currently one of the most popular approaches to study the regulatory architecture of vertebrate genomes. Fish-mammal genomic comparisons have proved powerful in identifying conserved non-coding elements likely to be distal <it>cis-</it>regulatory modules such as enhancers, silencers or insulators that control the expression of genes involved in the regulation of early development. The scientific community is showing increasing interest in characterizing the function, evolution and language of these sequences. Despite this, there remains little in the way of user-friendly access to a large dataset of such elements in conjunction with the analysis and the visualization tools needed to study them.</p> <p>Description</p> <p>Here we present CONDOR (COnserved Non-coDing Orthologous Regions) available at: <url>http://condor.fugu.biology.qmul.ac.uk</url>. In an interactive and intuitive way the website displays data on > 6800 non-coding elements associated with over 120 early developmental genes and conserved across vertebrates. The database regularly incorporates results of ongoing <it>in vivo </it>zebrafish enhancer assays of the CNEs carried out in-house, which currently number ~100. Included and highlighted within this set are elements derived from duplication events both at the origin of vertebrates and more recently in the teleost lineage, thus providing valuable data for studying the divergence of regulatory roles between paralogs. CONDOR therefore provides a number of tools and facilities to allow scientists to progress in their own studies on the function and evolution of developmental <it>cis</it>-regulation.</p> <p>Conclusion</p> <p>By providing access to data with an approachable graphics interface, the CONDOR database presents a rich resource for further studies into the regulation and evolution of genes involved in early development.</p

What’s going on in babies’ brains when they learn to do something?

Actions are important. We need to know how to do all sorts of actions in our everyday life, like using a fork to eat and using a pen to write. We understand actions we see other people do better if we’ve done the same action before ourselves. It helps us understand why other people choose to use the same action. Adults know lots of different actions, but babies are still learning how to do many things. They are just learning how to move around and how to play with new toys. Babies also understand more about actions they have done before than actions they haven’t done. Is there something happening in their brains that might help them understand the actions they have done? Do babies’ brains respond differently when they perceive an action they know how to do compared to one they have never done? Let’s find out

Gathering evidence- availability of published information to support zoonotic pathogen prioritization in swine within the Canadian context

Efforts to implement control programs for zoonotic pathogens at the farm level are ongoing. However, establishing control programs for pathogens that may derive from multiple food-animal sources and for which there are interventions at various levels of the food chain can be challenging. Prioritizing pathogens for control programs should be based on scientific evidence and transparent decision-making processes. As part of a larger project applying multi-criteria decision analysis for prioritizing pathogens, a systematic review of the literature is being conducted with initial focus on existing published research on the prevalence of 15 zoonotic pathogens in swine populations and in humans, as attributable to swine and pork, within the North American context

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation

Background Allergic disease affects 30% to 40% of the world's population, and its development is determined by the interplay between environmental and inherited factors. Air pollution, primarily consisting of diesel exhaust emissions, has increased at a similar rate to allergic disease. Exposure to diesel exhaust may play a role in the development and progression of allergic disease, in particular allergic respiratory disease. One potential mechanism underlying the connection between air pollution and increased allergic disease incidence is DNA methylation, an epigenetic process with the capacity to integrate gene-environment interactions. Objective We sought to investigate the effect of allergen and diesel exhaust exposure on bronchial epithelial DNA methylation. Methods We performed a randomized crossover-controlled exposure study to allergen and diesel exhaust in humans, and measured single-site (CpG) resolution global DNA methylation in bronchial epithelial cells. Results Exposure to allergen alone, diesel exhaust alone, or allergen and diesel exhaust together (coexposure) led to significant changes in 7 CpG sites at 48 hours. However, when the same lung was exposed to allergen and diesel exhaust but separated by approximately 4 weeks, significant changes in more than 500 sites were observed. Furthermore, sites of differential methylation differed depending on which exposure was experienced first. Functional analysis of differentially methylated CpG sites found genes involved in transcription factor activity, protein metabolism, cell adhesion, and vascular development, among others. Conclusions These findings suggest that specific exposures can prime the lung for changes in DNA methylation induced by a subsequent insult

Synergy between the Large Synoptic Survey Telescope and the Square Kilometre Array

We provide an overview of the science benefits of combining information from the Square Kilometre Array (SKA) and the Large Synoptic Survey Telescope (LSST). We first summarise the capabilities and timeline of the LSST and overview its science goals. We then discuss the science questions in common between the two projects, and how they can be best addressed by combining the data from both telescopes. We describe how weak gravitational lensing and galaxy clustering studies with LSST and SKA can provide improved constraints on the causes of the cosmological acceleration. We summarise the benefits to galaxy evolution studies of combining deep optical multi-band imaging with radio observations. Finally, we discuss the excellent match between one of the most unique features of the LSST, its temporal cadence in the optical waveband, and the time resolution of the SKA.Comment: SKA Synergies Chapter, Advancing Astrophysics with the SKA (AASKA14) Conference, Giardini Naxos (Italy), June 9th-13th 201

Promoting water efficiency and hydrocitizenship in young people’s learning about drought risk in a temperate maritime country

Engaging young citizens with drought risk and positive water behaviours is essential in domestic water demand management within the wider climate crisis. This paper evaluates a new research-informed, picture book—‘DRY: The Diary of a Water Superhero’—that explores UK drought. The book’s development was underpinned by research within the Drought Risk and You (DRY) project. The book’s concept and storyline were co-produced by an interdisciplinary team, including a creative practitioner. This focused on key themes: drought definitions and types; drought myths; adaptation and young people’s (YP) agency. Characters and storyline were co-created to promote YP’s autonomy as change agents, and to encourage intergenerational and community learning. This paper evaluates the book from three perspectives: of YP, trainee teachers (TT) and teachers. Emergent themes are triangulated: drought as a sensitive issue, subject knowledge and changes in behaviour, and YP’s misconceptions about drought and place. TT also contemplated their improved subject knowledge and barriers to engaging with positive water behaviours. Teachers reflected on classroom use of the book, prior experiences about teaching drought, curriculum context and st/age of YP engaged. This paper reflects on how these insights feed into school practice and water industry outreach, in developing effective learning resources that promote a valuing of water, behaviour change and wider hydrocitizenship among YP and their communities